Publications

2017

Wang H, Lutz AM, Hristov D, Tian L, Willmann JK. Intra-Animal Comparison Between 3D Molecular Imaging 3D Dynamic Contrast-enhanced Imaging for Early Anti-Angiogenic Treatment Assessment in Colon Cancer. Radiology 2017 Feb;282(2):443-452. PMID: 27490690. PMCID: In Process. |PDF

2016

Mullick Chowdhury S, Wang TY, Bachawal S, Devulapally R, Choe JW, Abou Elkacem L, Khuri Yakub B, Wang DS, Tian L, Paulmurugan R, Willmann JK. Ultrasound-Guided Therapeutic Modulation of Hepatocellular Crcinoma using Complementary microRNAs. J of Controlled Release 2016; Sep 28;238:272-80. PMID: 27503707. PMCID: PMC5185600. | PDF

Zhou J, Wang H, Zhang H, Lutz AM, Tian L, Hristov D, Willmann JK. VEGFR2-targeted Three-Dimensional Ultrasound Imaging Can Predict Responses to Anti-Angiogenic Therapy in Preclinical Models of Colon Cancer. Cancer Research 2016 15;76(14):4081-9. PMID: 27206846. PMCID: PMC5033689. | PDF

Valluru K, Willmann JK. Clinical Photoacoustic Imaging of Cancer. Ultrasonography 2016 Oct;35(4):267-80. PMID: 27669961. PMCID: PMC5040138. | PDF

Abou-Elkacem L, Wilson KE, Johnson SM, Mullick Chowdhury S, Bachawal S, Hackel BJ, Willmann JK. Ultrasound Molecular Imaging of the Breast Cancer Neovasculature Using Engineered Fibronectin Scaffold Ligands: A Novel Class of Targeted Contrast Ultrasound Agent. Theranostics 2016; Jun 6(11):1740-52. PMID: 27570547. PMCID: PMC4997233. | PDF

Valluru K, Wilson S, Willmann JK. Photoacoustic Imaging in Oncology: Translational Preclinical and Early Clinical Experience. Radiology 2016. Aug; 280(2):332-40. PMID: 2749141. PMCID: PMC4976462. | PDF

Qin J, Wang TY, Willmann JK. Sonoporation: Applications for Cancer Therapy. Adv Exp Med Biol. 2016;880:263-91. PMID: 26486343. PMCID: In Process. | PDF

2015

Machtaler S, Knieling F, Luong R, Tian L, Willmann JK. Assessment of Inflammation in an Acute on Chronic Model of Inflammatory Bowel Disease with Ultrasound Molecular Imaging. Theranostics 2015 Aug 8;5(11):1175-86. PMID: 26379784. PMCID: PMC4568446. | PDF

Wang TY, Wilson KE, Machtaler S, Willmann JK. Ultrasound and Microbubble Guided Drug Delivery: Mechanistic Understanding and Clinical Implications. Curr Pharm Biotechnol. 2014 Oct;14(8):743-52. PMID: 24372231. PMCID: 4084724.| PDF

Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. P Natl Acad Sci USA 2014. 29; 111(30):E3091-3100. PMID: 25024225, PMCID: PMC4121834 | PDF

Pysz MA, Machtaler SB, Seeley ES, Lee JJ, Brentnall TA, Rosenberg J, Tranquart F, Willmann JK. Vascular Endothelial Growth Factor Receptor Type 2-targeted Contrast-enhanced US of Pancreatic Cancer Neovasculature in a Genetically Engineered Mouse Model: Potential for Earlier Detection. Radiology 2015 Mar;274(3):790-9.PMID: 25322341 PMCID: PMC4372059 | PDF

Srinath Sampath, Srihari Sampath, Camila Mosci, Amelie Lutz, Willmann JK, Erik Mittra, Sanjiv Sam Gambhir, Andrei Iagaru. Detection of Osseous Metastasis by 18F NaF/18F FDG PET/CT versus CT Alone. Clin Nucl Med2015 Mar;40(3):e173-7. PMID: 25140557 PMCID: In Process | PDF

Laeseke PF, Chen R, Jeffrey RB, Brentnall TA, Willmann JK. Combining In Vitro Diagnostics with In Vivo Imaging for Earlier Detection of Pancreatic Ductal Adenocarcinoma: Challenges and Solutions. Radiology2015 Dec;277(3):644-61. PMID: 26599925. PMCID: PMC4666099. | PDF

Abou-Elkacem L, Bachawal SV, Willmann JK. Ultrasound molecular imaging: Moving toward clinical translation. Eur J Radiol. 2015 Mar 21. pii: S0720-048X(15)00138-2. PMID: 25851932 PMCID: PMC4545409. | PDF

Devulapally R, Sekar NM, Sekar TV, Foygel K, Massoud TF, Willmann JK, Paulmurugan R. Polymer nanoparticles mediated co-delivery of anti-miR-10b and anti-miR-21 for achieving triple negative breast cancer therapy. ACS Nano 2015 Mar 24;9(3):2290-302. PMID: 25652012 PMCID: PMC4374409 | PDF

Wang TY, Choe JW, Pu K, Devulapally R, Bachawal S, Machtaler S, Chowdhury SM, Luong R, Tian L, Khuri-Yakub B, Rao J, Paulmurugan R, Willmann JK. Ultrasound-guided Delivery of microRNA Loaded Nanoparticles into Cancer. Journal of Controlled Release 2015 Apr 10;203:99-108. PMID: 25687306 PMCID: PMC4373966 | PDF

Wang H, Kaneko OF, Tian L, Hristov D, Willmann JK. Three-dimensional Ultrasound Molecular Imaging of Angiogenesis in Colon Cancer using a Clinical Matrix Array Ultrasound Transducer. Invest Radiol 2015 May;50(5):322-9. PMID: 25575176 PMCID: PMC4470566. | PDF

Wang H, Felt SA, Machtaler S, Guracar I, Luong R, Bettinger T, Tian L, Lutz AM, Willmann JK. Quantitative Assessment of Inflammation in a Porcine Acute Terminal Ileitis Model: US with a Molecularly Targeted Contrast Agent. Radiology 2015 Sep;276(3):809-17. PMID: 25965901. PMCID: PMC4557395. | PDF

Wang H, Hristov D, Qin J, Tian L, Willmann JK. Three-dimensional Dynamic Contrast-enhanced Ultrasound Imaging for Early Anti-Angiogenic Treatment Assessment in a Mouse Colon Cancer Model. Radiology 2015 Nov;277(2):424-34. PMID: 26020439. PMCID: PMC4627439. | PDF

Kamaya A, Tahvildari A, Patel BN, Willmann JK, Jeffrey RB, Desser TS. Sonographic detection of extracapsular extension in papillary thyroid cancer. Journal of Ultrasound in Medicine 2015 Dec;34(12):2225-30. PMID: 26518279. PMCID: In Process | PDF

Bachawal SV, Jensen KC, Wison K, Tian L, Lutz AM, Willmann JK. Breast cancer detection by B7-H3 targeted ultrasound molecular imaging. Cancer Research 2015 Jun 15;75(12):2501-9. PMID: 25899053. PMCID: PMC4470725. Selected as cover article by the journal | PDF

Raghavan K, Jeffrey RB, Patel BN, DiMaio MA, Willmann JK, Olcott EW. MDCT Diagnosis of Perineural Invasion Involving the Celiac Plexus in Intrahepatic Cholangiocarinoma: Preliminary Observations and Clinical Implications. AJR Am J Roentgenol. 2015 Dec;205(6):W578-84. PMID: 26587947. PMCID: In Process. Selected as cover article by the journal | PDF

2014

Wilson KE, Bachawal SV, Tian L, Willmann JK. Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model. Theranostics. 2014 Aug 15;4(11):1062-71. doi: 10.7150/thno.9922. eCollection 2014. PMID: 25285161 [PubMed - in process]| PDF

Kim SH, Kamaya A, Willmann JK. CT perfusion of the liver: principles and applications in oncology.Radiology. 2014 Aug;272(2):322-44. doi: 10.1148/radiol.14130091. Review. PMID: 25058132 [PubMed - indexed for MEDLINE]| PDF

Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, Fitamant J, Jones PD, Ghanta KS, Kawano S, Nagle JM, Deshpande V, Boucher Y, Kato T, Chen JK, Willmann JK, Bardeesy N, Beachy PA. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3091-100. doi: 10.1073/pnas.1411679111. Epub 2014 Jul 14. PMID: 25024225 [PubMed - indexed for MEDLINE]| PDF

Lutz AM, Bachawal SV, Drescher CW, Pysz MA, Willmann JK, Gambhir SS. Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model. Clin Cancer Res. 2014 Mar 1;20(5):1313-22. doi: 10.1158/1078-0432.CCR-13-1642. Epub 2014 Jan 3. PMID: 24389327 [PubMed - indexed for MEDLINE]|PDF

2013

Wilson KE, Wang TY, Willmann JK. Acoustic and photoacoustic molecular imaging of cancer. J Nucl Med. 2013 Nov;54(11):1851-4. doi: 10.2967/jnumed.112.115568.| PDF

Chen IY, Gheysens O, Li Z, Rasooly JA, Wang Q, Paulmurugan R, Rosenberg J, Rodriguez-Porcel M, Willmann JK, Wang DS, Contag CH, Robbins RC, Wu JC, Gambhir SS. Noninvasive imaging of hypoxia-inducible factor-1? gene therapy for myocardial ischemia Hum Gene Ther Methods. 2013 Oct;24(5):279-88. doi: 10.1089/hgtb.2013.028. PMID:23937265 (PubMed - in process) | PDF

Foygel K, Wang H, Machtaler S, Lutz AM, Chen R, Pysz M, Lowe AW, Tian L, Carrigan T, Brentnall TA, Willmann JK. Detection of pancreatic ductal adenocarcinoma in mice by ultrasound imaging of thymocyte differentiation antigen 1. Gastroenterology. 2013 Oct;145(4):885-894.e3. doi: 10.1053/j.gastro.2013.06.011. Epub 2013 Jun 18. PMID: 23791701 (PubMed - in process) | PDF

Wang H, Machtaler S, Bettinger T, Lutz AM, Luong R, Bussat P, Gambhir SS, Tranquart F, Tian L, Willmann JK. Molecular Imaging of Inflammation in Inflammatory Bowel Disease with a Clinically Translatable Dual-Selectin-targeted US Contrast Agent: Comparison with FDG PET/CT in a Mouse Model. Radiology 2013 Jun;267(3):818-29 Selected for Editorial Article in Radiology 2013 | PDF

Panje CM, Wang DS, Willmann JK. Ultrasound and Microbubble-Mediated Gene Delivery in Cancer: Progress and Perspectives. Investigative Radiology 2013 May 21. PMID: 23791701

Kamaya A, Machtaler S, Sanjani Sahinaz Safari, Nikoozadeh A, Sommer FG, Khuri-Yakub BT, Willmann JK, Desser TD. New technologies in ultrasound. Semin Roentgenol 2013 Jul;48(3):214-23. PMID: 23796372 | PDF

Sekar TV, Foygel K, Willmann JK, Paulmurugan R. Dual-Therapeutic Reporter Genes Fusion for Enhanced Cancer Gene Therapy and Imaging. Gene Therapy 2013 May;20(5):529-37. | PDF

Bachawal SV, Jensen KC, Lutz AM, Gambhir SS, Tranquart F, Tian L, Willmann JK. Earlier Detection of Breast Cancer with Ultrasound Molecular Imaging in a Transgenic Mouse Model. Cancer Res. 2013 Jan 17. | PDF

2012

Kaneko OF, Willmann JK. Ultrasound for molecular imaging and therapy in cancer. Quant Imaging Med Surg2012;2(2):87-97 | PDF

Chen R, Pan S, Ottenhof NA, de Wilde RF, Wolfgang CL, Lane Z, Post J, Bronner MP, Willmann JK, Maitra A, Brentnall TA. Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma. Cancer Biol Ther. 2012 Aug 1;13(10). | PDF

Lehwald N, GZ Tao, Jang KY, Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG. β-catenin regulates hepatic mitochondrial function and energy balance in mice.Gastroenterology 2012 Sep;143(3):754-64. | PDF

Bettinger T, Bussat P, Tardy I, Pochon S, Hyvelin JM, Emmel P, Henrioud S, Biolluz N, Willmann JK, Schneider M, Tranquart F. Ultrasound molecular imaging contrast agent binding to both E and P-selectin in different species. Invest Radiol. 2012 Sep;47(9):516-23.

Kim DH, Kim SH, Im SA, Han SW, Goo JM, Willmann JK, Lee ES, Eo JS, Paeng JC, Han JK, Choi BI. Intermodality comparison between 3D perfusion CT and 18F-FDG PET/CT imaging for predicting early tumor response in patients with liver metastasis after chemotherapy: Preliminary results of a prospective study. Eur J Radiol 2012 Nov;81(11):3542-50. | PDF

Kimura RH, Teed R, Hackel BJ, Pysz MA, Chuang CZ, Sathirachinda A, Willmann JK, Gambhir SS. Pharmacokinetically stabilized cystine knot peptides that bind alpha-v-beta-6 integrin with single-digit nanomolar affinities for detection of pancreatic cancer. Clin Cancer Res. 2012; 1;18(3):839-49. | PDF

Padilla-Thornton AE, Willmann JK, Jeffrey RB. Adenocarcinoma of the uncinate process of the pancreas: MDCT patterns of local invasion and clinical features at presentation. Eur Radiology. 2012; 22(5):1067-74. |PDF

Goodman M, Willmann, JK, Jeffrey RB. Incidentally discovered solid pancreatic masses: imaging and clinical observations. Abdom Imaging. 2012 Feb;37(1):91-7. | PDF

Quantitative assessment of tumor angiogenesis using real-time motion-compensated contrast-enhanced ultrasound imaging. Pysz MA, Guracar I, Foygel K, Tian L, Willmann JKAngiogenesis. 2012 Sep;15(3):433-42. doi: 10.1007/s10456-012-9271-3. | PDF

Cationic versus neutral microbubbles for ultrasound-mediated gene delivery in cancer. Wang DS, Panje C, Pysz MA, Paulmurugan R, Rosenberg J, Gambhir SS, Schneider M, Willmann JKRadiology. 2012 Sep;264(3):721-32. doi: 10.1148/radiol.12112368. | PDF

Molecular body imaging: MR imaging, CT, and US. Part II. Applications. Kircher MF, Willmann JKRadiology. 2012 Aug;264(2):349-68. doi:10.1148/radiol.12111703. Review. | PDF

Ultrasound for molecular imaging and therapy in cancer.Kaneko OF, Willmann JKQuant Imaging Med Surg. 2012 Jun;2(2):87-97. | PDF

Fast microbubble dwell-time based ultrasonic molecular imaging approach for quantification and monitoring of angiogenesis in cancer. Pysz MA, Guracar I, Tian L, Willmann JKQuant Imaging Med Surg. 2012 Jun;2(2):68-80. | PDF

Molecular body imaging: MR imaging, CT, and US. part I. principles.Kircher MF, Willmann JKRadiology. 2012 Jun;263(3):633-43. doi: 10.1148/radiol.12102394. Review. | PDF

Antiangiogenic and radiation therapy: early effects on in vivo computed tomography perfusion parameters in human colon cancer xenografts in mice.Ren Y, Fleischmann D, Foygel K, Molvin L, Lutz AM, Koong AC, Jeffrey RB, Tian L, Willmann JKInvest Radiol. 2012 Jan;47(1):25-32. doi: 10.1097/RLI.0b013e31823a82f6. | PDF

Quantification and monitoring of inflammation in murine inflammatory bowel disease with targeted contrast-enhanced US. Deshpande N, Lutz AM, Ren Y, Foygel K, Tian L, Schneider M, Pai R, Pasricha PJ,Willmann JKRadiology. 2012 Jan;262(1):172-80. doi: 10.1148/radiol.11110323. | PDF

Ultrasound-mediated gene delivery with cationic versus neutral microbubbles: effect of DNA and microbubble dose on in vivo transfection efficiency. Panje CM, Wang DS, Pysz MA, Paulmurugan R, Ren Y, Tranquart F, Tian L,Willmann JKTheranostics. 2012;2(11):1078-91. doi: 10.7150/thno.4240. | PDF

 

2011

Lutz AM, Willmann, JK, Drescher CW, Ray P, Cochran FV, Urban N, Gambhir SS. Early diagnosis of ovarian carcinoma: is a solution in sight? Radiology. 2011; 259(2):329-345. | PDF

Targeted contrast-enhanced ultrasound: an emerging technology in abdominal and pelvic imaging. 
Pysz MA, Willmann JKGastroenterology. 2011 Mar;140(3):785-90. doi: 10.1053/j.gastro.2011.01.027. | PDF

Assessment and monitoring tumor vascularity with contrast-enhanced ultrasound maximum intensity persistence imaging. Pysz MA, Foygel K, Panje CM, Needles A, Tian L, Willmann JKInvest Radiol. 2011 Mar;46(3):187-95. doi: 10.1097/RLI.0b013e3181f9202d. | PDF

Tumor angiogenic marker expression levels during tumor growth: longitudinal assessment with molecularly targeted microbubbles and US imaging. Deshpande N, Ren Y, Foygel K, Rosenberg J, Willmann JKRadiology. 2011 Mar;258(3):804-11. doi: 10.1148/radiol.10101079. | PDF

 

2010

Antiangiogenic cancer therapy: monitoring with molecular US and a clinically translatable contrast agent (BR55). Pysz MA, Foygel K, Rosenberg J, Gambhir SS, Schneider M, Willmann JKRadiology. 2010 Aug;256(2):519-27. doi: 10.1148/radiol.10091858. | PDF

Molecular ultrasound imaging: current status and future directions. Deshpande N, Needles A, Willmann JK.Clin Radiol. 2010 Jul;65(7):567-81. doi:10.1016/j.crad.2010.02.013. Review. | PDF

Molecular imaging: current status and emerging strategies. Pysz MA, Gambhir SS, Willmann JK. Clin Radiol. 2010 Jul;65(7):500-16. doi:10.1016/j.crad.2010.03.011. Review. | PDF

Molecular ultrasound assessment of tumor angiogenesis. Deshpande N, Pysz MA, Willmann JKAngiogenesis. 2010 Jun;13(2):175-88. doi:10.1007/s10456-010-9175-z. | PDF

2009

Focal liver lesions: detection and characterization at double-contrast liver MR Imaging with ferucarbotran and gadobutrol versus single-contrast liver MR imaging. Heilmaier C, Lutz AM, Bolog N, Weishaupt D, Seifert B, Willmann JKRadiology. 2009 Dec;253(3):724-33. doi: 10.1148/radiol.2533090161. | PDF

MR angiography with parallel acquisition for assessment of the visceral arteries: comparison with conventional MR angiography and 64-detector-row computed tomography. Sutter R, Heilmaier C, Lutz AM, Weishaupt D, Seifert B, Willmann JKEur Radiol. 2009 Nov;19(11):2679-88. doi: 10.1007/s00330-009-1473-8. |PDF